Publications
Nanocluster-mediated signaling crosstalk between FcγR and TLR4 in macrophage inflammatory responses
Seonik Lee, Hunter Richman, Yan Yu*, Sci. Rep. 15, Article number: 12856 (2025)
Targeting the Weak Spot: Preferential Disruption of Bacterial Poles by Janus Nanoparticles
Danh Nguyen#, Swagata Bhattacharyya#, Hunter Richman, Yan Yu*, Ying Li*, Nano Letters ASAP, 2024.
#Equal contribution
Visualizing Single V-ATPase Rotation Using Janus Nanoparticles
Akihiro Otomo, Jared Wiemann, Swagata Bhattacharyya, Mayuko Yamamoto, Yan Yu*, Ryota Iino*
Nano Letters ASAP, 2024.
Quantitative cytotoxicity analysis of antibacterial Janus nanoparticles in immune and cancer cells
F1000Research (2024).
Cholesterol-Dependent Membrane Deformation by Metastable Viral Capsids Facilitates Entry
Jiao, M.; Danthi, P.*; Yu, Y.* ACS Infectious Disease, 10, 2728-40 (2024).
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse
Zhang, Z.; Gaetjens, T.; Ou, J.; Zhou, Q.; Yu, Y.-q; Mallory, D. P.; Abel, S. M.; Yu, Y.* Proceedings of the National Academy of Sciences USA, 2023, 120 (49) e2306788120.
Antibacterial Activity of Amphiphilic Janus Nanoparticles Enhanced by Polycationic Ligands
Wiemann, J.; Nguyen, D.; Bhattacharyya, S.; Li, Y.; Yu, Y.* ACS Applied Nano Materials, 2023, 6, 21, 20398–20409.
Timing of phagosome maturation depends on their transport switching from actin to microtubule tracks
Yu, Y.-q; Zhang, Z.; Yu, Y.* Journal of Physical Chemistry B, 2023, 127, 43, 9312–9322
Nanoparticles for Interrogation of Cell Signaling
S. Lee,§ M. Jiao,§ Z. Zhang,§ and Y. Yu.* Annual Reviews of Analytical Chemistry, 2023, 16, 333-351.
§ Equal contribution
Harnessing the Pre-metastatic Niche Macrophages through the Induction of Trained Immunity to Control Metastasis via the Sphingosine Lipid-Mitochondrial Fission Pathway
Ding, C.; et al. Yu, Y.; Yan, J.* Nature Immunology, 2023, 24, 239-254.
Domain-selective disruption and compression of phase-separated lipid vesicles by amphiphilic Janus nanoparticles
Wiemann, J. T.; Nguyen, D.; Li, Y.; Yu, Y.* iScience, 2022, 25, 105525.
Distinct Antibacterial Activities of Nanosized Cationic Liposomes against Gram-negative Bacteria Correlate with their Heterogeneous Fusion Interactions
Laune, M†., Zahidi†, S., Wiemann, J., Yu, Y.* ACS Applied Nano Materials, 2022, 5, 15201-15210.
† Undergrad researcher
Kinetics of phagosome maturation is coupled to their intracellular motility
Yu, Y., Zhang, Z., Walpole, G. F., & Yu, Y.* Communications Biology, 2022, 5, 1014.
Spatial Organization of Dectin-1 and TLR2 during Synergistic Crosstalk Revealed by Super-resolution Imaging
Li, M., Vultorius, C., Bethi, M., & Yu, Y.* J. Phys. Chem. B, 2022, 126, 5781-5792.
Immobile Ligands Enhance FcγR-TLR2/1 Crosstalk by Promoting Interface Overlap of Receptor Clusters
Li, M., Lee, S., Zahedian, M., Ding, C., Yan, J., & Yu, Y.* Biophysical Journal, 2022, 121, 966-976.
Dual-Color Peak Force Infrared Microscopy
Xie, Q.; Wiemann, J.; Yu, Y.; Xu, X. G.* Anal. Chem, 2022, 94, 1425-1431.
Single-phagosome imaging reveals that homotypic fusion impairs phagosome degradative function
Yu, Y., Jiao, M., Zhang, Z., & Yu, Y.* Biophysical Journal, 2022, 121, 495-469.
Anisotropic Presentation of Ligands on Cargos Modulates Degradative Function of Phagosomes
Jiao, M., Li, W., Yu, Y., & Yu, Y.* Biophysical Reports, 2022, 2, 100041.
Real-time Simultaneous Imaging of Acidification and Proteolysis in Single Phagosomes Using Bifunctional Janus Particle Probes
Lee, S.; Zhang, Z.; Yu, Y.* Angew. Chem. Int. Ed. 2021, 60, 26734–26739. News coverage
(Pedagogy) Individual development plans — experiences made in graduate student training
Flood, A.H., Skrabalak, S.E. & Yu, Y. Anal Bioanal Chem, 2021, 413, 5681–5684.
Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk
Liquid-Phase Peak Force Infrared Microscopy for Chemical Nanoimaging and Spectroscopy
Innate Immune Receptor Clustering and Its Role in Immune Regulation
Macrophage Activation on "Phagocytic Synapse" Arrays: Spacing of Nanoclustered Ligands Directs TLR1/2 Signaling with an Intrinsic Limit
Miao Li, Haomin Wang, Wenqian Li, Xiaoji G. Xu, and Yan Yu,* Science Advances, 2020, 6, eabc8482.
Membrane poration, wrinkling, and compression: deformations of lipid vesicles induced by amphiphilic Janus nanoparticles
Wiemann, J. T.; Shen, Z.; Ye, H.; Li, Y.; Yu, Y.* Nanoscale 2020, 12 (39), 20326–20336.
Simultaneous Nanoscale Imaging of Chemical and Architectural Heterogeneity on Yeast Cell Wall Particles
Li, W.; Wang, H.; Xu, X. G.; Yu, Y.* Langmuir 2020, 36 (22), 6169–6177.
Geometrical Reorganization of Dectin-1 and TLR2 on Single Phagosomes Alters Their Synergistic Immune Signaling
Li, W.; Yan, J.; Yu, Y.* Geometrical Reorganization of Dectin-1 and TLR2 on Single Phagosomes Alters Their Synergistic Immune Signaling. Proc. Natl. Acad. Sci. USA. 2019, 116, 25106-114.
Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?
Yu, Y.-q; Li, M.; Yu, Y.* ACS Nano2019, 13, 10860-68.
Lipid Bilayer Disruption Induced by Amphiphilic Janus Nanoparticles: The Non-Monotomic Effect of Charged Lipids
Lee, K.; Yu, Y.* Soft Matter 2019, 15, 2373-80.
"Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding
Yu, Y.-q; Gao, Y.; Yu, Y.* ACS Nano 2018, 12, 11871-80.
Selected as Editor's Choice.
Read the full news article here @ IUNewsRoom
Others News Reports: EurekAlert; Phys.Org; ScienceDaily; Bionity; Technology Networks; Nanowerk; Long Room; News Locker; QuantumTimes; BioPortfolio.
Lipid Bilayer Disruption by Amphiphilic Janus Nanoparticles: The Role of Janus Balance
Lee, K.; Yu, Y.* Langmuir 2018, 34, 12387-93.
Cargos Rotate at Microtubule Intersections during Intracellular Trafficking
Gao, Y.; Anthony, S. M.; Yu, Y.-q.; Yi, Y.; Yu, Y.* Biophys. J. 2018, 114, 2900-9.
Rupture of Lipid Membranes by Amphiphilic Janus Nanoparticles
Lee, K.; Zhang, L.; Yi, Y.; Wang, X.; Yu, Y.* ACS Nano 2018, 12, 3646-57.
Calcium Ion-Assisted Lipid Tubule Formation
Jones, S.;† Huynh, A.;† Gao, Y.; Yu, Y.* Mater. Chem. Front. 2018, 2, 603-8.
† Undergraduate researchers
Single-Janus Rod Tracking Reveals the "Rock-and-Roll" of Endosomes in Living Cells
Gao, Y.; Anthony, S. M.; Yi, Y.; Li, W.; Yu, Y.-q.; Yu, Y.* Single-Janus Rod Tracking Reveals the "Rock-and-Roll" of Endosomes in Living Cells. Langmuir 2018, 34, 1151-8.
Seeing the Unseen: Imaging Rotation in Cells with Designer Anisotropic Particles
Gao, Y.; Yu, Y.-q.; Sanchez, L.; Yu, Y.* Micron2017, 101, 123-31. [Editors' Choice]
Janus Nanoparticles for T Cell Activation: Clustering Ligands to Enhance Stimulation
Lee, K. and Yu, Y.* J. Mater. Chem. B 2017, 5, 4410-5.
Interrogating Cellular Functions with Designer Janus Particles
Yi, Y.; Sanchez, L.; Gao, Y.; Lee, K.; Yu, Y.* Chem. Mater. 2017, 29, 1448-60. [Cover image]
Effect of Partial PEGylation on Particle Uptake by Macrophages
Sanchez, L.; Yi, Y.; Yu, Y.* Nanoscale 2017, 9, 288-97. [In the news]
(Book chapter) Janus Particles for Biomedical Applications
Yi, Y.; Lee, K.; Sanchez, L.; Yu, Y.* In Soft, Hard and Hybrid Janus Structures; Lin, Z., Li, B., Eds.; World Scientific (Europe): London, 2017; pp 405-449.
Lipid Membrane-Assisted Condensation and Assembly of Amphiphilic Janus Particles
Chambers, M.,† Mallory, S. A., Malone, H., Gao, Y., Anthony, S. M., Yi, Y., Cacciuto, A.*, Yu, Y.* Soft Matter 2016, 12, 9151-7.
† Undergraduate researcher
Remote control of T cell activation using magnetic Janus particles
Lee, K., Yi, Y., Yu, Y.* Angew. Chem. Int. Ed. 2016, 55, 7384-7.
Janus particles for biological imaging and sensing
Yi, Y., Sanchez, L., Gao, Y., Yu, Y.* Analyst 2016, 141, 3526-39.
Tracking single particle rotation during macrophage uptake
Sanchez, L., Patton, P., Anthony, S. M., Yi, Y., Yu, Y.* Soft Matter2015, 11, 5346-52.
Tracking single particle rotation: Probing dynamics in four dimensions
Anthony, S.M., Yu, Y.* Anal. Methods2015, 7, 7020-28.
Macrophage uptake of Janus particles depends on Janus balance
Gao, Y., Yu, Y.* Langmuir2015, 31, 2833-2838.
Janus particles as artificial antigen-presenting cells for T cell activation
Chen, B.; Jia, Y.; Gao, Y.; Sanchez, L.; Anthony, S. M.; Yu, Y.* ACS Appl. Mater. Interfaces 2014, 6, 18435-9.
Size-based chromatography of signaling clusters in a living cell membrane
Caculitan, N. G.; Kai, H.; Liu, E. Y.; Fay, N.; Yu, Y.; Lohmuller, T.; O'Donoghue, G. P.; Groves, J. T. Nano Lett. 2014, 14, 2293-98.
Highlighted: Nat. Chem. Biol. 2014, 10, 408.
Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles
Sizovs, A.; Song, X.; Waxham, M. N.; Jia, Y.; Feng, F.; Chen, J.; Wicker, A. C.; Yu, Y.; Wang, J.* J. Am. Chem. Soc. 2014, 136, 234-240.
How Half-Coated Janus Particles Enter Cells
Gao, Y. and Yu, Y.* J. Am. Chem. Soc. 2013, 135, 19091-19094.
Modulation of T cell signaling by the actin cytoskeleton
Yu, Y.*, Smoligovets, A. A.; Groves, J. T.* J. Cell Sci.2013, 126, 1049-1058.
Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation
Yu, Y.; Fay, N. C.; Smoligovets, A. A.; Wu, H.; Groves, J. T. Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation. PLoS ONE 2012, 7, e30704.
How liposomes diffuse in a concentrated liposome suspension
Yu, Y.; Anthony, S. M.; Bae, S. C.; Granick, S. J. Phys. Chem. B 2011, 115, 2748-53.
Vesicle budding induced by pore-forming peptide
Yu, Y.; Vroman, J. A.; Bae, S. C.; Granick, S. J. Am. Chem. Soc. 2010, 132, 195-201. Highlighted: Nature 463, 439-40 (2010).
Pearling of lipid vesicles induced by nanoparticles
Yu, Y.; Granick, S. J. Am. Chem. Soc.2009, 131, 14158-59.
Biomolecular science of liposome-nanoparticle constructs
Yu, Y.; Anthony, S. M.; Bae, S. C.; Luijten, E.; Granick, S. Mol. Cryst. Liq. Cryst. 2009, 507, 18-25.
PCB association with model phospholipid bilayers
Campbell, A. S.; Yu, Y.; Granick, S.; Gewirth, A. A. Environ. Sci. Technol. 2008, 42, 7496-501.
Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones
Yu, Y.; Anthony, S. M.; Bae, S. C.; Granick, S. J. Phys. Chem. C 2007, 111, 8233-36.
Nanoparticle-assisted surface immobilization of phospholipid liposomes
Zhang, L.; Hong, L.; Yu, Y.; Bae, S. C.; Granick, S. J. Am. Chem. Soc.2006, 128, 9026-27.
Synthesis of an optically active triblock copolymer and its self-assembly behavior in dioxane/water
Zhang, J.; Yu, Y.; Wan, X.; Chen, X.; Zhou, Q.-F. Acta Polym. Sin. 2005, 1, 305-308.
The College of Arts